Barot-Ciorbaru R
C.N.R.S. URA 1116, Immunomodulateurs de Nocardiae, Université Paris-Sud, Orsay, France.
Int J Immunopharmacol. 1994 May-Jun;16(5-6):469-73. doi: 10.1016/0192-0561(94)90038-8.
The cells of Nocardia opaca are a source of potent immunostimulating substances, differing in solubility and in the presence or absence of peptidoglycan. Three classes of N. opaca fractions have been investigated: (1) NDCM (Nocardia delipidated cell mitogen), the starting fraction; (2) PG (peptidoglycan)-containing fractions: CW (cell walls), PG, and fractions containing soluble PG derivatives such as NWSM (Nocardia water soluble mitogen) and NSPD (Nocardia soluble peptidoglycan derivative); and (3) soluble fractions devoid of PG, such as NWSMP (NWSP-pellet) and CyI (cytoplasmic membrane). This report summarizes our results on the relationship between the structure of N. opaca fractions and their stimulatory activities on mouse, rabbit, germ-free piglet and human lymphocytes and monocytes/macrophages. The studies of biological properties of these compounds are the result of an extensive collaborative effort of several teams.
不透明诺卡氏菌的细胞是强效免疫刺激物质的来源，这些物质在溶解度以及是否存在肽聚糖方面存在差异。已对不透明诺卡氏菌的三类组分进行了研究：（1）NDCM（脱脂诺卡氏菌细胞促细胞分裂剂），起始组分；（2）含PG（肽聚糖）的组分：CW（细胞壁）、PG，以及含有可溶性PG衍生物的组分，如NWSM（诺卡氏菌水溶性促细胞分裂剂）和NSPD（诺卡氏菌可溶性肽聚糖衍生物）；（3）不含PG的可溶性组分，如NWSMP（NWSP沉淀）和CyI（细胞质膜）。本报告总结了我们关于不透明诺卡氏菌组分的结构与其对小鼠、兔子、无菌仔猪及人淋巴细胞和单核细胞/巨噬细胞的刺激活性之间关系的研究结果。这些化合物生物学特性的研究是多个团队广泛合作的成果。
