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The HA-1A saga: the scientific and ethical dilemma of innovative and costly therapies.

作者信息

Brun-Buisson C

出版信息

Intensive Care Med. 1994 May;20(5):314-6. doi: 10.1007/BF01720901.

DOI:10.1007/BF01720901
PMID:7930023
Abstract
摘要

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Structure, Function, and Therapeutic Use of IgM Antibodies.IgM抗体的结构、功能及治疗用途
Antibodies (Basel). 2020 Oct 13;9(4):53. doi: 10.3390/antib9040053.
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Human monoclonal antibodies from transgenic mice.来自转基因小鼠的人源单克隆抗体。
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The cytokine response to critical illness.细胞因子对危重病的反应。

本文引用的文献

1
Critical appraisal of therapeutic interventions in the intensive care unit: human monoclonal antibody treatment in sepsis. Journal Club of the Hamilton Regional Critical Care Group.重症监护病房治疗干预的批判性评估:脓毒症的人单克隆抗体治疗。汉密尔顿地区重症监护小组期刊俱乐部
J Intensive Care Med. 1992 Nov-Dec;7(6):275-82. doi: 10.1177/088506669200700601.
2
Cost-effectiveness of monoclonal antibodies to gram-negative endotoxin in the treatment of gram-negative sepsis in ICU patients.单克隆抗体治疗重症监护病房革兰阴性菌败血症患者革兰阴性内毒素的成本效益分析
JAMA. 1993 Jan 13;269(2):249-54.
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Introduction of new technology into critical care practice: a history of HA-1A human monoclonal antibody against endotoxin.
J Accid Emerg Med. 1996 May;13(3):154-62. doi: 10.1136/emj.13.3.154.
新技术在重症监护实践中的应用:抗内毒素HA-1A人单克隆抗体的历史
Crit Care Med. 1993 Aug;21(8):1233-41. doi: 10.1097/00003246-199308000-00026.
4
The French National Registry of HA-1A (Centoxin) in septic shock. A cohort study of 600 patients. The National Committee for the Evaluation of Centoxin.法国脓毒性休克患者HA-1A(商品名:Centoxin)全国注册研究。一项针对600例患者的队列研究。Centoxin评估全国委员会。
Arch Intern Med. 1994 Nov 14;154(21):2484-91.
5
HA-1A in septic patients with ARDS: results from the pivotal trial.ARDS 脓毒症患者中的 HA-1A:关键试验结果
Intensive Care Med. 1994 May;20(5):328-34. doi: 10.1007/BF01720904.
6
The regulation of investigational drugs.研究用药物的监管
N Engl J Med. 1989 Feb 2;320(5):281-8. doi: 10.1056/NEJM198902023200504.
7
Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group.使用抗内毒素的HA-1A人单克隆抗体治疗革兰氏阴性菌血症和感染性休克。一项随机、双盲、安慰剂对照试验。HA-1A脓毒症研究组。
N Engl J Med. 1991 Feb 14;324(7):429-36. doi: 10.1056/NEJM199102143240701.
8
Monoclonal antibodies to endotoxin. New allies against sepsis?抗内毒素单克隆抗体。对抗败血症的新盟友?
JAMA. 1991 Aug 28;266(8):1125-6.
9
Cost-effectiveness of HA-1A monoclonal antibody for gram-negative sepsis. Economic assessment of a new therapeutic agent.HA - 1A单克隆抗体治疗革兰氏阴性菌败血症的成本效益。一种新型治疗药物的经济学评估。
JAMA. 1991 Dec 25;266(24):3466-71.
10
Anti-endotoxin monoclonal antibodies.
N Engl J Med. 1992 Apr 23;326(17):1153-7. doi: 10.1056/NEJM199204233261711.