Foëx B A, Shelly M P
North Western Injury Research Centre, University of Manchester.
J Accid Emerg Med. 1996 May;13(3):154-62. doi: 10.1136/emj.13.3.154.
The aims of this review are to provide a basic introduction to the biology of cytokines and to summarise the results of studies, both laboratory and clinical, relating to the cytokine response to critical illness. Elucidation of the cytokine response to conditions such as sepsis, trauma, and burns may be important for several reasons. It may improve understanding of the pathophysiological processes triggered by these insults. It may allow the severity of the insult to be gauged, and maybe even provide prognostic information about individual patients. Similarly it may allow the effectiveness of resuscitation and further treatment to be monitored. Finally, knowing about the cytokine response may provide the key to developing new treatments.
本综述的目的是提供细胞因子生物学的基本介绍，并总结实验室研究和临床研究中有关细胞因子对危重病反应的结果。阐明细胞因子对败血症、创伤和烧伤等病症的反应可能因多种原因而具有重要意义。这可能有助于更好地理解这些损伤引发的病理生理过程。它可能使人们能够评估损伤的严重程度，甚至可能为个体患者提供预后信息。同样，它也可能有助于监测复苏和进一步治疗的效果。最后，了解细胞因子反应可能为开发新的治疗方法提供关键。
