Hunter C A, Litton M J, Remington J S, Abrams J S
Department of Medicine, Stanford University School of Medicine.
J Infect Dis. 1994 Oct;170(4):939-45. doi: 10.1093/infdis/170.4.939.
BALB/c mice develop toxoplasmic encephalitis (TE) but the pathology resolves; in contrast, CBA/Ca mice develop progressive TE. Immunohistochemical analysis revealed peak staining for interferon-gamma (IFN-gamma) and tumor necrosis factor (TNF) in lymph nodes of both strains on day 7 of infection, with elevated levels of IFN-gamma and TNF persisting in CBA/Ca mice. TNF was present in the central nervous systems (CNS) of both strains of mice and correlated with severity of pathology. Interleukin (IL)-2 was detected in lymph nodes and CNS of CBA/Ca mice after day 52 of infection and only in the lymph nodes of BALB/c mice between days 14 and 21 after infection. Highest levels of IL-10 were observed in lymph nodes and CNS of infected CBA/Ca mice. Variations in cytokine levels in lymph nodes and CNS of these mouse strains may account for differences in their susceptibility to TE.
BALB/c小鼠会患上弓形虫性脑炎（TE），但其病理状况会消退；相比之下，CBA/Ca小鼠会患上进行性TE。免疫组织化学分析显示，在感染第7天时，两种品系小鼠的淋巴结中干扰素-γ（IFN-γ）和肿瘤坏死因子（TNF）的染色达到峰值，且CBA/Ca小鼠中IFN-γ和TNF水平持续升高。TNF存在于两种品系小鼠的中枢神经系统（CNS）中，且与病理严重程度相关。感染52天后，在CBA/Ca小鼠的淋巴结和CNS中检测到白细胞介素（IL）-2，而在感染后14至21天之间，仅在BALB/c小鼠的淋巴结中检测到IL-2。在受感染的CBA/Ca小鼠的淋巴结和CNS中观察到最高水平的IL-10。这些小鼠品系的淋巴结和CNS中细胞因子水平的差异可能解释了它们对TE易感性的差异。
