Saji M, Taguchi S, Ohkuni H
Section of Pharmaceutics, First Hospital Nippon Medical School.
Kansenshogaku Zasshi. 1994 Aug;68(8):953-9. doi: 10.11150/kansenshogakuzasshi1970.68.953.
The MBCs of Ac against P. aeruginosa (7 strains) isolated from infected skin lesions of patients were more than 6400 micrograms/ml, and those of Gv were more than 1600 micrograms/ml. When either Ac or Gv was used independently, these dyes did not have the bactericidal effect of P. aeruginosa. When Gv was used in combination with Ac, predominantly synergism on the bactericidal effect of Ac and Gv against P. aeruginosa was observed. The MBCs of an Ac-Gv cocktail were between 100 micrograms/ml and 225 micrograms/ml. We have previously reported that Gv possessed significantly a bactericidal effect to MRSA isolated from clinical specimens. Therefore, these results suggested that a combination treatment by an Ac-Gv cocktail may be one of the useful drugs for the MRSA and P. aeruginosa mixed infection on the skin lesions which is frequently observed clinically.
从患者感染性皮肤损伤中分离出的醋酸氯己定（Ac）对铜绿假单胞菌（7株）的最低杀菌浓度（MBC）大于6400微克/毫升，葡萄糖酸氯己定（Gv）的MBC大于1600微克/毫升。当单独使用Ac或Gv时，这些染料对铜绿假单胞菌没有杀菌作用。当Gv与Ac联合使用时，主要观察到Ac和Gv对铜绿假单胞菌的杀菌作用具有协同性。Ac-Gv混合液的MBC在100微克/毫升至225微克/毫升之间。我们之前报道过Gv对从临床标本中分离出的耐甲氧西林金黄色葡萄球菌（MRSA）具有显著的杀菌作用。因此，这些结果表明，Ac-Gv混合液联合治疗可能是临床上常见的皮肤损伤处MRSA和铜绿假单胞菌混合感染的有效药物之一。
