具有异亮氨酸80的Bw4阳性HLA等位基因可选择性抑制NK3特异性自然杀伤细胞。
NK3-specific natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine 80.
作者信息
Cella M, Longo A, Ferrara G B, Strominger J L, Colonna M
机构信息
Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.
出版信息
J Exp Med. 1994 Oct 1;180(4):1235-42. doi: 10.1084/jem.180.4.1235.
Abstract
Natural killer (NK) cell clones have been previously described which are inhibited by HLA-C alleles with Asn77-Lys80 (NK1-specific cells) or by HLA-C alleles with Ser77-Asn80 (NK2-specific cells). In the present work, the generation of NK cells with HLA-B-related specificities was attempted by stimulation of a Bw4 homozygous responder by a Bw6 homozygous donor. Two NK clones were found, which were inhibited by HLA-Bw4 (but not by HLA-Bw6) allotypes and by some HLA-A allotypes that share the Bw4 public epitope. Inhibition of NK cell-mediated lysis strongly correlated with the presence of an Ile residue at position 80 of the protective allele. These NK cell clones define a new specificity termed NK3.
摘要
先前已描述了自然杀伤（NK）细胞克隆，其被具有Asn77 - Lys80的HLA - C等位基因（NK1特异性细胞）或具有Ser77 - Asn80的HLA - C等位基因（NK2特异性细胞）所抑制。在本研究中，尝试通过Bw6纯合供体刺激Bw4纯合应答者来产生具有HLA - B相关特异性的NK细胞。发现了两个NK克隆，它们被HLA - Bw4（而非HLA - Bw6）同种异型以及一些共享Bw4公共表位的HLA - A同种异型所抑制。NK细胞介导的细胞溶解的抑制与保护性等位基因第80位存在异亮氨酸残基密切相关。这些NK细胞克隆定义了一种新的特异性，称为NK3。
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