心脏单胺氧化酶活性随年龄变化的种属差异。
Species differences in changes of heart monoamine oxidase activities with age.
作者信息
Strolin Benedetti M, Thomassin J, Tocchetti P, Dostert P, Kettler R, Da Prada M
机构信息
Farmitalia Carlo Erba, Research and Development-Erbamont Group, Milan, Italy.
出版信息
J Neural Transm Suppl. 1994;41:83-7. doi: 10.1007/978-3-7091-9324-2_10.
It has previously been established that MAO-A activity markedly increases (about 600%) with age in the rat heart. The aim of the present study was to examine the effect of age on the activity of MAO-A and -B in the mouse heart. In contrast to the rat heart, beta-phenylethylamine is deaminated by MAO-B in the mouse heart. Heart MAO-B activity was found to significantly increase (about 70%) with age in both male and female mice, whereas MAO-A activity remained unchanged. Compared to age-matched rats, serotonin-deaminating activity was about 35 times and 204 times lower in young and old mice, respectively.
先前已经确定，在大鼠心脏中，单胺氧化酶A（MAO-A）的活性会随着年龄的增长而显著增加（约600%）。本研究的目的是检测年龄对小鼠心脏中MAO-A和MAO-B活性的影响。与大鼠心脏不同，在小鼠心脏中，β-苯乙胺由MAO-B脱氨基。研究发现，雄性和雌性小鼠心脏中的MAO-B活性均会随着年龄的增长而显著增加（约70%），而MAO-A活性则保持不变。与年龄匹配的大鼠相比，年轻和老年小鼠中5-羟色胺脱氨基活性分别低约35倍和204倍。
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