Sparks P J, Daniell W, Black D W, Kipen H M, Altman L C, Simon G E, Terr A I
Providence Medical Center, Seattle, Washington 98122.
J Occup Med. 1994 Jul;36(7):731-7.
Multiple chemical sensitivity syndrome (MCS) does not appear to fit established principles of toxicology. Social, political, and economic forces are demanding that MCS be defined medically, even though scientific studies have failed as yet to identify pathogenic mechanisms for the condition or any objective diagnostic criteria. Consequently, a working definition of MCS can only rely on a person's subjective symptoms of distress and attribution to environmental exposures rather than currently measurable objective evidence of disease. Nevertheless, patients labeled with MCS are clearly distressed and many are functionally disabled. Without reconciling the different theories of etiology of MCS discussed in Part I of this report, and recognizing that the cause of the syndrome may be multifactorial, strategies are proposed for clinical evaluation and management of patients with MCS using a biopsychosocial model of illness. The social implications of this illness are also discussed.
多重化学物质敏感综合征（MCS）似乎不符合既定的毒理学原理。社会、政治和经济力量要求从医学角度对MCS进行定义，尽管科学研究尚未确定该病症的致病机制或任何客观诊断标准。因此，MCS的现行定义只能依赖于个体的主观不适症状以及将其归因于环境暴露，而非目前可测量的疾病客观证据。然而，被诊断为MCS的患者明显感到痛苦，许多人功能受限。在不调和本报告第一部分所讨论的MCS不同病因理论的情况下，并认识到该综合征的病因可能是多因素的，本文提出了使用生物心理社会疾病模型对MCS患者进行临床评估和管理的策略。同时也讨论了该疾病的社会影响。
