Oner L, Kaş H S, Hincal A A
University of Hacettepe, Faculty of Pharmacy, Pharmaceutical Technology Department, Ankara, Turkey.
J Microencapsul. 1988 Jul-Sep;5(3):225-9. doi: 10.3109/02652048809064167.
In this study a 2(3) factorial design has been applied to the evaluation of dissolution characteristics of zinc sulphate microcapsules. The kinetic model according to the Rosin-Rimmler-Sperling-Bennet-Weillbull (RRSBW) distribution was applied for the parametric representation of the dissolution curves. The effect of three factors; core: wall ratio, amount of zinc sulphate and particle size of the microcapsules, on the dissolution rate of zinc sulphate were studied at two levels. The factorial design method proved to be useful for the examination of microcapsules.
在本研究中，采用了2（3）析因设计来评估硫酸锌微胶囊的溶出特性。根据罗辛-里姆勒-斯珀林-贝内特-韦布尔（RRSBW）分布的动力学模型用于溶出曲线的参数表征。研究了三个因素：核壁比、硫酸锌用量和微胶囊粒径，在两个水平下对硫酸锌溶出速率的影响。结果表明，析因设计方法对微胶囊的研究是有用的。
