Ferguson A, Sedgwick D M
University of Edinburgh.
J R Coll Physicians Lond. 1994 May-Jun;28(3):220-7.
We interviewed and examined 70 young adults (50 Crohn's disease, 20 ulcerative colitis) from a geographically derived cohort of patients with juvenile-onset (< or = 16 years) inflammatory bowel disease at a mean of 14 years (range 5.2-29.5) after diagnosis. Patients with initially ileo-colonic Crohn's disease spent significantly longer in hospital than other groups. Thirty-nine Crohn's disease and 10 ulcerative colitis patients have had major surgery, with permanent stomas in 15 cases of Crohn's disease and seven of ulcerative colitis. In Crohn's disease the disease was still active at the time of review in 16 of 50 patients (10 of 20 women), whereas only two of the 20 patients with ulcerative colitis had active disease. The data show that the high early morbidity of juvenile-onset inflammatory bowel disease continues into adult life, with particularly severe and disabling manifestations in women with Crohn's disease.
我们对70名青年成人进行了访谈和检查，这些患者来自一个按地理位置划分的青少年发病（≤16岁）炎症性肠病队列，诊断后平均14年（范围5.2 - 29.5年）。最初患有回结肠型克罗恩病的患者住院时间明显长于其他组。39名克罗恩病患者和10名溃疡性结肠炎患者接受了大手术，15例克罗恩病患者和7例溃疡性结肠炎患者有永久性造口。在克罗恩病患者中，50例中有16例（20名女性中的10例）在复查时疾病仍处于活动期，而20例溃疡性结肠炎患者中只有2例有活动性疾病。数据显示，青少年发病的炎症性肠病早期高发病率持续至成年期，在患有克罗恩病的女性中表现尤为严重且致残。
