Kauste A
Acta Anaesthesiol Scand. 1976;20(4):369-77. doi: 10.1111/j.1399-6576.1976.tb05052.x.
The suitability of Althesin as a short-acting anaesthetic agent was studied by comparing it to methohexitone. Twenty-eight anaestheias were given using equipotent doses of the two anaesthetics in order to anaesthetize 14 patients once with each drug. Thus the patients served as their own controls. Sleep induced by Althesin averaged 7 minutes, which was slightly but not statistically significantly longer than that produced by methohexitone (average 6 minutes). The time taken until orientation of the patients was complete was considerably longer with Althesin than with methohexitone. The responses to Althesin had a much wider range of individual variation in induction time, duration of anaesthesia and orientation time. After Althesin, three patients displayed mental confusion with anxiety on awakening. The recovery from anaesthesia was assessed by several recovery tests and observations, in addition to the patients' subjective assessments. Drowsiness was more manifest and persisted longer following Althesin than after methohexitone. Ninety minutes after anaesthesia, a tendency to collapse on standing was obvious following methohexitone, but this was not seen after Althesin. The level of test values and the physical status of the patients returned to pre-anaesthetic levels within 2 hours after both agents. The majority of the patients found anaesthesia with both compounds pleasant. However, they seemed to favour methohexitone as regards pleasantness and their subjective impression was of faster awakening or less postanaesthetic drowsiness.
通过将阿尔thesin与甲己炔巴比妥进行比较，研究了阿尔thesin作为短效麻醉剂的适用性。使用两种麻醉剂的等效剂量进行了28次麻醉，以便用每种药物对14名患者各进行一次麻醉。因此，患者作为自身对照。阿尔thesin诱导的睡眠时间平均为7分钟，略长于甲己炔巴比妥诱导的睡眠时间（平均6分钟），但在统计学上无显著差异。与甲己炔巴比妥相比，使用阿尔thesin后患者完全清醒所需的时间长得多。阿尔thesin在诱导时间、麻醉持续时间和清醒时间方面的个体差异范围要大得多。使用阿尔thesin后，三名患者醒来时出现精神错乱和焦虑。除了患者的主观评估外，还通过多项恢复测试和观察来评估麻醉恢复情况。与甲己炔巴比妥相比，使用阿尔thesin后嗜睡更明显且持续时间更长。麻醉90分钟后，使用甲己炔巴比妥后患者站立时有明显的虚脱倾向，但使用阿尔thesin后未观察到这种情况。两种药物使用后，测试值水平和患者身体状况在2小时内恢复到麻醉前水平。大多数患者认为使用这两种药物进行麻醉都很舒适。然而，就舒适度而言，他们似乎更喜欢甲己炔巴比妥，并且他们的主观印象是醒来更快或麻醉后嗜睡更少。
