Patwari A K, Srinivasan A, Diwan N, Aneja S, Anand V K, Peshin S
Diarrhoea Training and Treatment Unit, Kalawati Saran Children's Hospital, New Delhi, India.
J Trop Pediatr. 1994 Aug;40(4):214-8. doi: 10.1093/tropej/40.4.214.
Four-hundred children below 3 years of age with acute watery diarrhoea were studied over a 12-month period for detection of rotavirus (RV) antigen in the stool samples. Detection of RV antigen in the cases has been compared with 175 age-matched non-diarrhoea controls. Overall positivity for detection of RV antigen was 6 per cent which is much lower than earlier studies. Even during the peak season the RV antigen detection was positive only in 13 per cent cases. However, RV antigen detection was significantly higher in cases than in the controls (P < 0.05). No significant correlation was noticed between the detection of RV antigen in the stool and environmental temperature, rainfall, and relative humidity except for higher percentage of RV antigen detection between February and April. Clinical profile of cases with RV antigen-positive stools has been compared with RV antigen-negative controls. Preceding history of vomiting and respiratory symptoms were noticed in higher percentage of RV antigen-positive cases, but no reliable 'clinical predictor' could be identified to differentiate RV diarrhoea from non-RV diarrhoea. Presence or absence of fecal polymorphonuclear leucocytes do not seem to rule out or suggest RV diarrhoea.
在12个月的时间里，对400名3岁以下患有急性水样腹泻的儿童进行了研究，以检测其粪便样本中的轮状病毒（RV）抗原。已将病例中RV抗原的检测结果与175名年龄匹配的非腹泻对照进行了比较。RV抗原检测的总体阳性率为6%，远低于早期研究。即使在高峰期，RV抗原检测也仅在13%的病例中呈阳性。然而，病例中RV抗原的检测显著高于对照组（P < 0.05）。除了2月至4月期间RV抗原检测的百分比更高外，粪便中RV抗原的检测与环境温度、降雨量和相对湿度之间未发现显著相关性。已将RV抗原阳性粪便病例的临床特征与RV抗原阴性对照进行了比较。RV抗原阳性病例中，呕吐和呼吸道症状的既往史比例更高，但无法确定可靠的“临床预测指标”来区分RV腹泻和非RV腹泻。粪便中多形核白细胞的有无似乎不能排除或提示RV腹泻。
