Nikulina L B
Antibiotiki. 1978 Jun;23(6):543-8.
The study of the effect of actinomycin D, karminomycin and bleomycin used alone or in combination with zimozan or serotonine on the functional state of the peritoneal macrophages showed that the use of the antibiotics in mice without tumors induced a decrease mainly in the absorptive capacity of the macrophages not changing significantly their digestive activity. The same antibiotics did not significantly change the initial low values of the functional activity of the cells in mice with transplantable tumors. The use of zimozan after completeness of the treatment course with actinomycin D, karminomycin and bleomycin in mice without tumors had a stimulating effect on the functional activity of the macrophages. Zimozan had a stimulating effect on the functional activity of the cells in mice with transplantable tumors only on its use after completeness of the treatment course with actinomycin D or bleomycin. Serotonine in combination with the above antibiotics had no stimulating effect on the functional activity of macrophages in mice both with and without tumors.
关于放线菌素D、卡米诺霉素和博来霉素单独使用或与齐莫赞或血清素联合使用对腹膜巨噬细胞功能状态影响的研究表明，在无肿瘤小鼠中使用这些抗生素主要导致巨噬细胞吸收能力下降，而其消化活性无显著变化。相同的抗生素对可移植肿瘤小鼠细胞的初始低功能活性值没有显著影响。在无肿瘤小鼠中，用放线菌素D、卡米诺霉素和博来霉素完成治疗疗程后使用齐莫赞，对巨噬细胞的功能活性有刺激作用。齐莫赞仅在放线菌素D或博来霉素完成治疗疗程后用于可移植肿瘤小鼠时，对细胞的功能活性有刺激作用。血清素与上述抗生素联合使用，对有肿瘤和无肿瘤小鼠巨噬细胞的功能活性均无刺激作用。
