Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran.
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R, Iran.
J Ovarian Res. 2020 Mar 5;13(1):24. doi: 10.1186/s13048-020-00626-7.
Cervical cancer is the fourth-ranked cancer in the world and is associated with a large number of deaths annually. Chemotherapy and radiotherapy are known as the common therapeutic approaches in the treatment of cervical cancer, but because of their side effects and toxicity, researchers are trying to discovery alternative therapies. Beta-glucans, a group of glucose polymers that are derived from the cell wall of fungi, bacteria, and etc. it has been showed that beta-glucans have some anti-cancer properties which due to their impacts on adaptive and innate immunity. Along to these impacts, these molecules could be used as drug carriers. In this regard, the application of beta-glucans is a promising therapeutic option for the cancer prevention and treatment especially for cervical cancer. Herein, we have summarized the therapeutic potential of beta-glucans alone or as adjuvant therapy in the treatment of cervical cancer. Moreover, we highlighted beta-glucans as drug carriers for preventive and therapeutic purposes.
宫颈癌是全球排名第四的癌症，每年都有大量患者因此死亡。化疗和放疗是宫颈癌治疗的常用方法，但由于其副作用和毒性，研究人员正在试图寻找替代疗法。β-葡聚糖是一组葡萄糖聚合物，来源于真菌、细菌等的细胞壁。已经表明β-葡聚糖具有一些抗癌特性，这是由于它们对适应性和先天性免疫的影响。除了这些影响外，这些分子还可以用作药物载体。在这方面，β-葡聚糖的应用是预防和治疗癌症的一种很有前途的治疗选择，特别是对宫颈癌。在此，我们总结了β-葡聚糖单独或作为辅助治疗在宫颈癌治疗中的治疗潜力。此外，我们强调了β-葡聚糖作为药物载体在预防和治疗方面的应用。
