[机械通气期间一种新型一氧化氮输送系统的评估]
[Evaluation of a new nitric oxide delivery system during mechanical ventilation].
作者信息
Noguchi T, Miyakawa H, Mori M, Kitano T, Iwasaka H, Oda S, Taniguchi K, Honda N
机构信息
Intensive Care Unit, Oita Medical University Hospital.
出版信息
Masui. 1994 Jul;43(7):1083-6.
A new nitric oxide delivery and continuous monitoring system is described. During mechanical ventilation, this new system connected with Siemens Servo 900C ventilator was shown to be able to provide a constant inspired NO concentration (10-100 ppm) using chemiluminescence technique for NO analysis. Gas was analysed at the mixing chamber in front of the ventilator inlet and inspiratory tube connected with the soda-lime carbon-dioxide absorber. Both NO concentrations showed a good correlation (r = 0.99). The actual NO concentration from the NO supply cylinder was 1154 ppm and NO2 concentration was 14 ppm. In mongrel dogs, after 20 minutes of NO inhalation (10-100 ppm), the blood methemoglobin level reached a peak value of 2.2% starting from the pre-inhalation level of 0%. To optimize the safety of the clinical application of NO, its concentration should be measured continuously with chemiluminescence technique.
描述了一种新的一氧化氮输送和连续监测系统。在机械通气期间，该新系统与西门子Servo 900C呼吸机相连，结果表明，使用化学发光技术进行一氧化氮分析时，它能够提供恒定的吸入一氧化氮浓度（10 - 100 ppm）。在呼吸机入口前的混合室以及与碱石灰二氧化碳吸收器相连的吸气管处对气体进行分析。两种一氧化氮浓度显示出良好的相关性（r = 0.99）。来自一氧化氮供应气瓶的实际一氧化氮浓度为1154 ppm，二氧化氮浓度为14 ppm。在杂种犬中，吸入一氧化氮（10 - 100 ppm）20分钟后，血液高铁血红蛋白水平从吸入前的0%达到峰值2.2%。为优化一氧化氮临床应用的安全性，应使用化学发光技术连续测量其浓度。
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