1例神经白塞病的临床病理研究：特别提及MRI、SPECT及神经病理学 findings。 （这里“findings”直接保留英文更合适，因为医学领域很多时候会保留特定英文术语，若强行翻译为“发现”会显得生硬且不符合医学文献习惯，所以整体译文为：1例神经白塞病的临床病理研究：特别提及MRI、SPECT及神经病理学表现 ） 完整译文：1例神经白塞病的临床病理研究：特别提及MRI、SPECT及神经病理学表现
Clinicopathological study on a case of neuro-Behçet's disease: in special reference to MRI, SPECT and neuropathological findings.
作者信息
Arai T, Mizukami K, Sasaki M, Tanaka Y, Shiraishi H, Horiguchi H, Ogata T
机构信息
Department of Psychiatry, University of Tsukuba, Ibaraki, Japan.
出版信息
Jpn J Psychiatry Neurol. 1994 Mar;48(1):77-84. doi: 10.1111/j.1440-1819.1994.tb03000.x.
A case of neuro-Behçet's disease with dementia and personality changes is described with magnetic resonance imaging (MRI), single photon emission tomography (SPECT) and neuropathological findings. MRI disclosed high signal areas in the cerebral white matter and the brain stem. SPECT showed a marked reduction of blood flow in the frontal cortex. Neuropathologically, multifocal necrotizing lesions with perivascular lymphocytic infiltration and glial proliferation were detected mainly in the brain stem, namely the midbrain and the pons. From these findings, it is suggested that mental disorders of neuro-Behçet's disease are related to the secondary dysfunction of the frontal cortex due to the damage of the subcortical structures, mainly the brain stem.
本文描述了一例伴有痴呆和人格改变的神经白塞病患者的磁共振成像（MRI）、单光子发射断层扫描（SPECT）及神经病理学检查结果。MRI显示脑白质和脑干存在高信号区。SPECT显示额叶皮质血流明显减少。神经病理学检查发现，多灶性坏死性病变伴血管周围淋巴细胞浸润和胶质细胞增生，主要见于脑干，即中脑和脑桥。根据这些发现，提示神经白塞病的精神障碍与皮质下结构（主要是脑干）受损导致额叶皮质继发性功能障碍有关。
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