Kane F J
Am J Obstet Gynecol. 1976 Dec 15;126(8):968-72. doi: 10.1016/0002-9378(76)90686-4.
A review of available clinical studies indicates that 10 to 40 per cent of oral contraceptive users may suffer mild to moderate depression syndromes. Clinical and animal data indicate that a variety of mechanisms may be involved, including alterations in folate, pyridoxine, and vitamine B12 metabolism, as well as related effects on biogenic amine metabolism. Interactive effects may result, such as impairment of usual coping mechnisms and psychological defenses by altered central nervous system function.
对现有临床研究的回顾表明，10%至40%的口服避孕药使用者可能会出现轻度至中度的抑郁综合征。临床和动物数据表明，可能涉及多种机制，包括叶酸、吡哆醇和维生素B12代谢的改变，以及对生物胺代谢的相关影响。可能会产生相互作用的影响，例如中枢神经系统功能改变对通常的应对机制和心理防御的损害。
