Scott S A, Liang S, Weingartner J A, Crutcher K A
Department of Neurosurgery, University of Cincinnati College of Medicine, OH 45267-0515.
Neurobiol Aging. 1994 May-Jun;15(3):337-46. doi: 10.1016/0197-4580(94)90029-9.
Sympathetic sprouting in the hippocampus following septal denervation is thought to involve nerve growth factor (NGF). This sprouting response is dramatically reduced in aged rats, but immunological assays reveal no age-related decline in hippocampal NGF levels. In the present study, both a bioassay and an immunoassay were used to examine the effect of a medial septal lesion on hippocampal NGF levels in young adult (2-5 months) and aged (24 months) Fischer 344 rats. No significant differences were detected between normal young and aged rats, in agreement with earlier results. Following medial septal lesions, however, only young rats demonstrated significant increases in hippocampal NGF-like activity. These results support the hypothesis that the age-related deficit in sympathetic sprouting results from an attenuated neurotrophic response to hippocampal denervation.
隔区去神经支配后海马中的交感神经发芽被认为与神经生长因子（NGF）有关。这种发芽反应在老年大鼠中显著降低，但免疫分析显示海马NGF水平没有与年龄相关的下降。在本研究中，采用生物测定法和免疫测定法来检测内侧隔区损伤对年轻成年（2 - 5个月）和老年（24个月）Fischer 344大鼠海马NGF水平的影响。与早期结果一致，正常年轻和老年大鼠之间未检测到显著差异。然而，在内侧隔区损伤后，只有年轻大鼠海马中NGF样活性显著增加。这些结果支持了以下假设：交感神经发芽中与年龄相关的缺陷是由于对海马去神经支配的神经营养反应减弱所致。
