Yokomatsu H, Satake K, Hiura A, Tsutsumi M, Suganuma M
First Department of Surgery, Osaka City University Medical School, Japan.
Pancreas. 1994 Jul;9(4):526-30.
Sarcophytol A (SaA), a cembrane-type diterpene isolated from the marine soft coral Sarcophyton glaucum showed anticancer and cancer preventive effects in two different experiments. Growth of transplanted human pancreatic cancer cells (MIA paca-2, 1 x 10(7)) in nude mice (BALB/C 4W female) (Experiment 1) and pancreatic carcinogenesis induced by N-nitrobis-(2-hydroxypropyl) amine (BHP, 500 mg/kg) in Syrian golden hamsters (7W female) (Experiment 2) were inhibited by feeding the animals a diet containing 0.01% SaA. In Experiment 1, on day 29 after transplantation, tumor volume was significantly less in the SaA group than in the control group (1,759 + 310 mm3 vs. 2,364 + 467 mm3) (p < 0.05). In Experiment 2, the incidence of pancreatic tumors in the SaA group was 42.8% and that in the control group was 90.0% at 25-27 weeks. Thus, pancreatic carcinoma developed more slowly in the SaA group than in the control group. In addition, the incidence of atypical ductal hyperplasia and carcinoma in situ was lower in the SaA group. These results indicate that oral SaA administration is an effective vehicle for inhibition of certain types of cancer in hamsters.
从海洋软珊瑚肉芝软珊瑚中分离得到的西松烷型二萜类化合物——肉芝软珊瑚醇A（SaA），在两项不同实验中显示出抗癌及防癌作用。在实验1中，给裸鼠（BALB/C 4周龄雌性）喂食含0.01% SaA的饲料，可抑制移植的人胰腺癌细胞（MIA paca - 2，1×10⁷）的生长；在实验2中，给叙利亚金仓鼠（7周龄雌性）喂食含0.01% SaA的饲料，可抑制由N - 二（2 - 羟丙基）亚硝胺（BHP，500 mg/kg）诱导的胰腺癌发生。在实验1中，移植后第29天，SaA组的肿瘤体积显著小于对照组（1759 + 310 mm³ 对 2364 + 467 mm³）（p < 0.05）。在实验2中，25 - 27周时，SaA组胰腺肿瘤的发生率为42.8%，对照组为90.0%。因此，SaA组胰腺癌的发展比对照组更慢。此外，SaA组非典型导管增生和原位癌的发生率更低。这些结果表明，口服SaA是抑制仓鼠某些类型癌症的有效途径。
