大剂量酮洛芬与吲哚美辛治疗类风湿关节炎的对比试验。
A comparative trial of large doses of ketoprofen and indomethacin in the treatment of rheumatoid arthritis.
作者信息
El-Ghobarey A F, Rennie J A, Hadidi T, Hamid H A, Mavrikakis M
出版信息
Curr Med Res Opin. 1976;4(6):432-5. doi: 10.1185/03007997609111999.
A 4-weeks' double-blind, crossover study in 30 patients with definite or classical rheumatoid arthritis is reported using 300 mg ketoprofen per day and 150 mg indomethacin per day. Both drugs had similar effects upon the patients' subjective improvement of pain. Objectively, the results also suggest that ketoprofen may be more effective in reducing the articular index, i.e. a superior analgesic effect. Further studies are underway to assess the value of ketoprofen administered in high dosage for longer duration.
报道了一项针对30例确诊或典型类风湿性关节炎患者进行的为期4周的双盲交叉研究，患者分别每日服用300毫克酮洛芬和150毫克吲哚美辛。两种药物对患者疼痛主观改善的效果相似。客观上，结果还表明酮洛芬在降低关节指数方面可能更有效，即具有更好的镇痛效果。正在进行进一步研究以评估高剂量、长时间服用酮洛芬的价值。
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