[丙型肝炎与慢性酒精性肝病]
[Hepatitis C and chronic alcoholic hepatopathy].
作者信息
Pagani A, Sala N, Zigliani P, Galante T
机构信息
Divisione di Medicina Generale 2, USSL 34, Presidio Ospedaliero di Rovato, Brescia.
出版信息
Recenti Prog Med. 1994 Sep;85(9):429-32.
We evaluated hepatitis C virus prevalence in 105 patients with chronic alcoholic liver disease by research of antibodies to hepatitis C virus (anti-HCV) by second generation recombinant based enzyme immunosorbent to assay and immunoblot to assay. 46 patients of 105 (43.7%) were anti-HCV positive: 2 in steatosis group (9.5%), 3 in steatofibrosis (23%), 10 in chronic active hepatitis (66.6%), 22 in cirrhosis (59.4%) and 9 in hepatocellular carcinoma (47.3%). These patients had higher levels of serum gammaglobulin and transaminases than seronegative patients. We think that there is a correlation between high prevalence of antibodies anti-HCV and the evolution of damage in chronic alcoholic liver disease.
我们通过第二代基于重组酶免疫吸附测定法和免疫印迹测定法检测丙型肝炎病毒抗体，评估了105例慢性酒精性肝病患者的丙型肝炎病毒感染率。105例患者中有46例（43.7%）抗丙型肝炎病毒抗体呈阳性：脂肪变性组2例（9.5%），脂肪纤维化组3例（23%），慢性活动性肝炎组10例（66.6%），肝硬化组22例（59.4%），肝细胞癌组9例（47.3%）。这些患者的血清γ球蛋白和转氨酶水平高于血清阴性患者。我们认为抗丙型肝炎病毒抗体的高感染率与慢性酒精性肝病损害的进展之间存在关联。
Zotero 插件