Amitrano L, Ascione A, Canestrini C, D'Agostino S, Iaccarino L, Vacca C, Gigliotti T
Divisione di Gastroenterologia, Ospedale A Cardarelli, Napoli, Italy.
Ital J Gastroenterol. 1990 Feb;22(1):16-8.
Two hundred and sixty-three patients consecutively admitted to our Unit for CLD were investigated for the antibody to Hepatitis C Virus (anti-HCV) in the serum using the recently developed enzyme immunoassay. The overall prevalence of anti-HCV was 45%; in patients with cryptogenic CLD it was significantly higher (69%) than in patients with markers of viral hepatitis (15%). Anti-HCV was found in 62% of the patients with hepatocellular carcinoma; this finding favours a potential role of HCV in determining the neoplastic transformation of the cirrhotic liver. In alcoholic liver disease the prevalence of anti-HCV was 52%; this finding poses the interesting question of aethiology of liver damage in these patients. The presence of anti-HCV was significantly associated with older age, irrespective of aethiology and stage of liver disease. The importance of the detection of this antibody for the aethiological diagnosis of chronic liver damage remains to be elucidated.
我们科室连续收治的263例慢性肝病（CLD）患者，采用最新开发的酶免疫分析法检测血清中的丙型肝炎病毒抗体（抗-HCV）。抗-HCV的总体患病率为45%；隐源性CLD患者的患病率（69%）显著高于有病毒性肝炎标志物的患者（15%）。肝细胞癌患者中62%检测到抗-HCV；这一发现支持HCV在肝硬化肝脏肿瘤转化中可能发挥的作用。酒精性肝病患者中抗-HCV的患病率为52%；这一发现提出了这些患者肝损伤病因学的有趣问题。无论肝病的病因和阶段如何，抗-HCV的存在都与年龄较大显著相关。该抗体检测对慢性肝损伤病因诊断的重要性仍有待阐明。
