Bourhis J, Dupuis O
Institut Gustave-Roussy (radiothérapie et pharmacologie moléculaire), Villejuif.
Rev Prat. 1994 Apr 1;44(7):900-5.
Only a limited number of human viruses have been shown to have oncogenic properties, including the retrovirus HTLV1 and 2, the hepatitis B virus (HBV), the Epstein-Barr virus (EBV), and some human papillomas virus (HPV). Epidemiologic and molecular biological studies have shown that these viruses were involved as cofactors in the multistep process of carcinogenesis. Viral DNA probes or antibodies against viral proteins can prove to be useful tools for diagnostic (HTLV1, EBV, HBV) or prognosis (HPV) of some cancers. A better knowledge of these viruses may also have therapeutic implications in a not too distant future such as the vaccination against HBV in order minimize the incidence of hepatocellular carcinoma in endemic countries.
仅有少数人类病毒被证明具有致癌特性，包括逆转录病毒HTLV1和2、乙型肝炎病毒（HBV）、爱泼斯坦-巴尔病毒（EBV）以及一些人乳头瘤病毒（HPV）。流行病学和分子生物学研究表明，这些病毒在癌症发生的多步骤过程中作为辅助因子发挥作用。针对病毒蛋白的病毒DNA探针或抗体可成为某些癌症诊断（HTLV1、EBV、HBV）或预后评估（HPV）的有用工具。对这些病毒的更深入了解在不久的将来可能也具有治疗意义，例如通过接种乙肝疫苗以降低乙肝流行国家肝细胞癌的发病率。
