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The yeast YKL741 gene situated on the left arm of chromosome XI codes for a homologue of the human ALD protein.

作者信息

Bossier P, Fernandes L, Vilela C, Rodrigues-Pousada C

机构信息

Lab. Genética Molecular, Instituto Gulbenkian de Ciência, Oeiras, Portugal.

出版信息

Yeast. 1994 May;10(5):681-6. doi: 10.1002/yea.320100512.

DOI:10.1002/yea.320100512
PMID:7941751
Abstract

The yeast gene YKL741 is situated on the left arm of chromosome XI, 12 kb closer to the centromere with respect to the previously localized PAS1 gene. The new yeast gene codes for a homologue of the human ALD protein (ALD: adrenoleukodystrophy). The similarity between the YKL741 protein and the ALD protein is very high in the C-terminal half, which contains an ATP-binding cassette characteristic of the ABC family of transporters. Additionally the YKL741 protein shows some similarity to the ALD protein in the N-terminal half in three putative transmembrane spanning domains. The sequence has been deposited in the EMBL data library under Accession Number X76133 SC YKL.

摘要

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