Zamboni M, Armellini F, Cominacini L, Turcato E, Todesco T, Bissoli L, Micciolo R, Bergamo-Andreis I A, Bosello O
Institutes of Internal Medicine, University of Verona, Policlinico di Borgo Roma, Italy.
Am J Clin Nutr. 1994 Nov;60(5):682-7. doi: 10.1093/ajcn/60.5.682.
Relationships between obesity and fat distribution as evaluated by computed tomography and metabolic variables were studied in 35 men. Significant correlations emerged between body mass index and sum of glucose during oral glucose load and HDL3 triglycerides and also between visceral abdominal fat and triglycerides, apolipoprotein B, sum of insulin during oral glucose load, very-low-density-lipoprotein (VLDL) cholesterol, and VLDL and low-density-lipoprotein (LDL) triglycerides. Visceral abdominal fat correlated negatively with the ratio of HDL to LDL cholesterol. When the subjects were subdivided into four groups according to body mass index (< or = 26.7, > 26.7) and median visceral abdominal fat, no significant differences were found in body mass index, whereas significant differences were found for triglycerides, cholesterol, apolipoprotein B, VLDL cholesterol, HDL:LDL cholesterol, and VLDL triglycerides. Our study shows that the amount of visceral abdominal fat is the most relevant factor for metabolic abnormalities. Our data also suggest that the effect of visceral fat is independent of body mass index.
对35名男性进行了研究，以评估通过计算机断层扫描所测定的肥胖与脂肪分布以及代谢变量之间的关系。体重指数与口服葡萄糖负荷期间的葡萄糖总量以及高密度脂蛋白3甘油三酯之间出现了显著相关性，同时内脏腹部脂肪与甘油三酯、载脂蛋白B、口服葡萄糖负荷期间的胰岛素总量、极低密度脂蛋白（VLDL）胆固醇以及VLDL和低密度脂蛋白（LDL）甘油三酯之间也存在显著相关性。内脏腹部脂肪与高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的比值呈负相关。当根据体重指数（≤26.7，>26.7）和内脏腹部脂肪中位数将受试者分为四组时，体重指数未发现显著差异，而甘油三酯、胆固醇、载脂蛋白B、VLDL胆固醇、高密度脂蛋白：低密度脂蛋白胆固醇以及VLDL甘油三酯存在显著差异。我们的研究表明，内脏腹部脂肪量是代谢异常的最相关因素。我们的数据还表明，内脏脂肪的影响独立于体重指数。
