Rigaud D, Angel L A, Cerf M, Carduner M J, Melchior J C, Sautier C, René E, Apfelbaum M, Mignon M
Department of Nutrition, Hopital Bichat-Claude Bernard, Paris, France.
Am J Clin Nutr. 1994 Nov;60(5):775-81. doi: 10.1093/ajcn/60.5.775.
Because weight loss is common in colonic Crohn's disease and is poorly correlated with disease activity, we analyzed food intake in 63 patients without malabsorption, 30 patients with weight loss (9.2 +/- 4.2 kg), and 33 patients without weight loss. Energy and protein intakes were lower in patients with weight loss than in those with stable weight (P < 0.01). In the former group, food restrictions were more numerous (P < 0.01) and visual analog scales showed less hunger, decreased appetite, and fewer sensations of pleasure related to eating, as compared with the other group (P < 0.01). Food intake reduction was also related to depressive mood and medical advice. However, there was no difference between groups in fecal energy wasting and resting energy expenditure. Weight loss in Crohn's disease may be due to a decrease in food intake rather than to an increase in energy cost of the disease. Thus, focus of attention on the diet is crucial to prevent malnutrition.
由于体重减轻在结肠克罗恩病中很常见，且与疾病活动度相关性较差，我们分析了63例无吸收不良的患者、30例体重减轻（9.2±4.2千克）的患者和33例体重未减轻的患者的食物摄入量。体重减轻患者的能量和蛋白质摄入量低于体重稳定的患者（P<0.01）。在前一组中，食物限制更多（P<0.01），与另一组相比，视觉模拟量表显示饥饿感更低、食欲下降以及与进食相关的愉悦感更少（P<0.01）。食物摄入量减少也与抑郁情绪和医嘱有关。然而，两组在粪便能量消耗和静息能量消耗方面没有差异。克罗恩病患者体重减轻可能是由于食物摄入量减少而非疾病能量消耗增加所致。因此，关注饮食对于预防营养不良至关重要。
