Garry V F, Kelly J T, Sprafka J M, Edwards S, Griffith J
Laboratory of Environmental Medicine and Pathology, University of Minnesota, Minneapolis.
Arch Environ Health. 1994 Sep-Oct;49(5):337-43. doi: 10.1080/00039896.1994.9954984.
We surveyed 1,000 randomly selected state-licensed pesticide appliers to improve our understanding of pesticide use and its potential health effects. Participants were stratified by pesticide class (herbicides, insecticides, fungicides, fumigants) to determine potential differences in health characteristics among different pesticide groups. A subset of 60 applicators, divided by pesticide class used, were studied for exposure-related cholinesterase (ChE) depression. ChE depression in excess of 20% was most frequent in fumigant applicators who did enclosed-space application, in addition to other pesticide application procedures (p < .05). Survey data demonstrated that the prevalence of all common chronic diseases considered together was significantly increased (p = .015) in fumigant appliers, compared with all other pesticide use groups. The frequency of chronic lung disease was also significantly increased in the fumigant applier group (p = .027). Curiously, two cases of a rare hematopoietic neoplasm--hairy cell leukemia--were identified in our study group (annual incidence 0.67/100,000 in Minnesota). Whether there is an association between this unique tumor and agricultural work is uncertain, and further study is needed in this regard.
我们对1000名随机挑选的获得州政府许可的农药施用者进行了调查，以增进我们对农药使用及其潜在健康影响的了解。参与者按农药类别（除草剂、杀虫剂、杀菌剂、熏蒸剂）进行分层，以确定不同农药组之间健康特征的潜在差异。对60名施用者按所使用的农药类别进行分组，研究与接触相关的胆碱酯酶（ChE）抑制情况。除其他农药施用程序外，进行密闭空间熏蒸剂施用的施用者中，ChE抑制超过20%的情况最为常见（p < 0.05）。调查数据表明，与所有其他农药使用组相比，熏蒸剂施用者中所有常见慢性病的总体患病率显著增加（p = 0.015）。熏蒸剂施用者组中慢性肺病的发生率也显著增加（p = 0.027）。奇怪的是，我们的研究组中发现了两例罕见的造血系统肿瘤——毛细胞白血病（明尼苏达州的年发病率为0.67/100,000）。这种独特的肿瘤与农业工作之间是否存在关联尚不确定，在这方面需要进一步研究。
