分子生物学与放射肿瘤学家

Molecular biology and the radiation oncologist.

作者信息

Kearsley J H, Lavin M F

机构信息

Department of Radiation Oncology, St George Hospital, Kogarah, NSW, Australia.

出版信息

Australas Radiol. 1994 Aug;38(3):215-20. doi: 10.1111/j.1440-1673.1994.tb00178.x.

DOI:10.1111/j.1440-1673.1994.tb00178.x

PMID:7945117

Abstract

An overview is provided of several recent advances in our understanding of the molecular events that occur when cells are exposed to ionizing radiation. A basic knowledge of molecular radiobiology is necessary so that the radiation oncologist can (i) screen cancer patients for an abnormally reduced or exaggerated response to radiotherapy; and (ii) devise novel ways to counter the molecular pathways that sustain malignant progression.

摘要

本文概述了近年来我们对细胞暴露于电离辐射时发生的分子事件的一些新认识。分子放射生物学的基础知识是必要的，这样放射肿瘤学家才能：（i）筛查癌症患者对放疗的反应是否异常降低或过度；（ii）设计新方法来对抗维持恶性进展的分子途径。