Head and Neck Unit, The Royal Marsden Hospital, London, UK.
Clin Oncol (R Coll Radiol). 2013 Oct;25(10):569-77. doi: 10.1016/j.clon.2013.06.009. Epub 2013 Jul 10.
A comprehensive, mechanistic understanding of radiobiological phenomena that can be integrated within the broader context of cancer biology offers the prospect of transforming clinical practice in radiation oncology. In this review, we revisit the six established biological hallmarks of cancer and examine how they have provided insights into novel therapeutic strategies. In addition, we discuss the potential of two emerging hallmarks to continue to expand our understanding beyond the narrow confines of the traditional 5Rs of radiobiology.
全面、机制化地理解放射生物学现象，并将其整合到癌症生物学的更广泛背景中，有望改变放射肿瘤学的临床实践。在这篇综述中，我们重新审视了癌症的六个已确立的生物学标志，并探讨了它们如何为新的治疗策略提供了见解。此外，我们还讨论了两个新兴标志的潜力，以继续扩大我们对传统放射生物学的 5R 之外的狭隘范围的理解。
