Pingree B J, Pethybridge R J
Institute of Naval Medicine, Alverstoke, Gosport, Hants., UK.
Aviat Space Environ Med. 1994 Jul;65(7):597-605.
Scopolamine was compared with cinnarizine in a double-blind sea trial involving 179 subjects from the crews of 2 warships. Medication was initiated prophylactically when weather information indicated the approach of nauseogenic conditions. Ship motion was measured during drug treatment periods. In one ship, moderate to severe nauseogenic conditions were encountered; a parallel group comparison was achieved in this. In the other ship, the motion experienced was of a mild nature; a crossover comparison was achieved. Scopolamine was shown to be more effective than cinnarizine in protecting against the symptoms of seasickness. In mild motion, cinnarizine was better tolerated than scopolamine in having less marked side effects. As motion severity increased, the comparative tolerability of scopolamine improved.
在一项双盲海上试验中，将东莨菪碱与桂利嗪进行了比较，该试验涉及两艘军舰船员中的179名受试者。当天气信息表明致呕条件即将出现时，预防性地开始用药。在药物治疗期间测量船舶运动。在一艘船上，遇到了中度至重度致呕情况；在此进行了平行组比较。在另一艘船上，经历的运动性质较轻；进行了交叉比较。结果表明，在预防晕船症状方面，东莨菪碱比桂利嗪更有效。在轻度运动中，桂利嗪的耐受性优于东莨菪碱，副作用不那么明显。随着运动严重程度的增加，东莨菪碱的相对耐受性有所改善。
