Tokola O, Laitinen L A, Aho J, Gothoni G, Vapaatalo H
Aviat Space Environ Med. 1984 Jul;55(7):636-41.
In two placebo-controlled, double-blind, randomized trials scopolamine (0.3 mg) alone or combined with ephedrine (25 mg) was tested for its effectiveness in the prevention of seasickness during 24 h at sea and of motion sickness in rotating chair tests in a laboratory. Scopolamine was effective both alone and in combination with ephedrine, which supports the hypothesis on central cholinergic overactivity in the pathogenesis of motion sickness. Ephedrine did not markedly increase the effectiveness of scopolamine. Side-effects were slight and did not disturb the operating ability of the volunteers.
在两项安慰剂对照、双盲、随机试验中，单独使用东莨菪碱（0.3毫克）或与麻黄碱（25毫克）联合使用，对其在海上24小时预防晕船以及在实验室转椅试验中预防晕动病的有效性进行了测试。东莨菪碱单独使用以及与麻黄碱联合使用均有效，这支持了晕动病发病机制中中枢胆碱能活动过度的假说。麻黄碱并未显著提高东莨菪碱的有效性。副作用轻微，未干扰志愿者的操作能力。
