Shen D, Wang Y
Department of Nuclear Medicine, Space Central Hospital, Beijing, P. R. China.
Aviat Space Environ Med. 1994 Jul;65(7):646-8.
In order to evaluate the effect of hypoxia on platelet activation, 53 pilots were chosen for this study. Thirty were selected as the hypoxic group, and the other 23 as a control group. The plasma concentration of thromboxane B2(TXB2), 6-keto-prostaglandin f1 alpha (6-keto-PGF1 alpha), beta-thrombo-globulin (BTG) and platelet factor 4 (PF4) were measured during altitude chamber tests. After staying at 5000 m for 15 min, the plasma level of TXB2, BTG and PF4 increased significantly over pre-test levels (p < 0.01), but 6-keto-PGF1 alpha had no distinct change (p > 0.05). These changes indicate that moderate acute hypoxia causes increases in platelet activation, but has less effects on the endothelial cells.
为了评估缺氧对血小板活化的影响，本研究选取了53名飞行员。其中30人被选为缺氧组，另外23人作为对照组。在高空舱试验期间测量血栓素B2（TXB2）、6-酮-前列腺素F1α（6-酮-PGF1α）、β-血小板球蛋白（BTG）和血小板因子4（PF4）的血浆浓度。在5000米停留15分钟后，TXB2、BTG和PF4的血浆水平比试验前显著升高（p < 0.01），但6-酮-PGF1α没有明显变化（p > 0.05）。这些变化表明，中度急性缺氧会导致血小板活化增加，但对内皮细胞的影响较小。
