类风湿性关节炎患者中Vβ17阳性T细胞频率增加。
Increased frequency of V beta 17-positive T cells in patients with rheumatoid arthritis.
作者信息
Zagon G, Tumang J R, Li Y, Friedman S M, Crow M K
机构信息
Hospital for Special Surgery/Cornell University Medical College, New York, New York 10021.
出版信息
Arthritis Rheum. 1994 Oct;37(10):1431-40. doi: 10.1002/art.1780371005.
OBJECTIVE
To identify the T lymphocytes that mediate disease in rheumatoid arthritis (RA).
METHODS
A panel of monoclonal antibodies reactive with T cell receptor (TCR) V beta gene products was used to analyze the RA T cell repertoire.
RESULTS
Of 5 TCR V beta gene products studied, only V beta 17-positive T cells were increased in peripheral blood and synovial fluid (SF) from RA patients, compared with controls (P < 0.01 and P = 0.0006, respectively). Thirty-one percent of the 49 RA SF samples and none of the 19 non-RA SF samples contained > 10% V beta 17-positive T cells. Activated (Tac-positive) T cells were enriched among V beta 17-positive synovial T cells.
CONCLUSION
The selective increase of V beta 17-positive T cells suggests a role for those T cells in the pathogenesis of RA.
目的
鉴定在类风湿关节炎（RA）中介导疾病的T淋巴细胞。
方法
使用一组与T细胞受体（TCR）Vβ基因产物反应的单克隆抗体来分析RA患者的T细胞库。
结果
在所研究的5种TCR Vβ基因产物中，与对照组相比，RA患者外周血和滑液（SF）中仅Vβ17阳性T细胞增加（分别为P < 0.01和P = 0.0006）。49份RA SF样本中有31%且19份非RA SF样本中均无> 10%的Vβ17阳性T细胞。活化的（Tac阳性）T细胞在Vβ17阳性滑膜T细胞中富集。
结论
Vβ17阳性T细胞的选择性增加表明这些T细胞在RA发病机制中起作用。
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