Gordon J
Dept of Immunology, The Medical School, Birmingham, UK.
Immunol Today. 1994 Sep;15(9):411-7. doi: 10.1016/0167-5699(94)90270-4.
Although CD23 and CD72 are well-known B-cell signalling molecules, the intracellular signal transduction pathways through which they operate remain poorly elucidated. This may partly reflect their somewhat dubious histories, with claims and counterclaims being made for functions and ligands. Here, John Gordon discusses why such controversy should surround the two B-cell-associated C-type lectins and provides speculation as to their respective roles in regulating an immune response that may be different in mice and humans.
尽管CD23和CD72是众所周知的B细胞信号分子，但它们所介导的细胞内信号转导途径仍未完全阐明。这可能部分反映了它们有些可疑的历史，关于其功能和配体存在诸多说法和反驳。在此，约翰·戈登讨论了为何围绕这两种与B细胞相关的C型凝集素会存在如此多争议，并推测了它们在调节免疫反应中各自可能发挥的作用，而这些作用在小鼠和人类中可能有所不同。
