人类妊娠晚期母胎免疫球蛋白G及其亚类的转运
Maternal-fetal transport of immunoglobulin G and its subclasses during the third trimester of human pregnancy.
作者信息
Malek A, Sager R, Schneider H
机构信息
Department of Obstetrics and Gynecology, University of Berne, Switzerland.
出版信息
Am J Reprod Immunol. 1994 Aug;32(1):8-14. doi: 10.1111/j.1600-0897.1994.tb00873.x.
PROBLEM
We determined the maternal-fetal transport of immunoglobulin G (IgG) during the third trimester of human pregnancy.
METHOD
The concentration of IgG and its subclasses (IgG1-4) was determined in sera of blood samples from 38 pregnancies collected at the time of delivery from a peripheral maternal vein (MV) and from the placental umbilical artery (UA) and vein (UV). Gestational age varied between 28 and 42 weeks (WG).
RESULT
Whereas placental weight showed a significant correlation with gestational age, the maternal level of IgG and the ratio of its subclasses did not vary with gestational age. At 28-33 WG (n = 15) the mean values in the UA (5.91 +/- 1.53 g/l) and UV (6.41 +/- 1.57 g/l) for total IgG concentration were lower than in the MV (10.74 +/- 2.55 g/l). At the end of gestation (37-42 WG, n = 12), IgG in both UA (11.21 +/- 1.95 g/l) and UV (12.26 +/- 2.06 g/l) exceeded the maternal concentration (9.69 +/- 1.84 g/l). In addition to the significant positive correlation between IgG concentration in the fetal circulation (UV + UA) and gestational age (28-42 WG), an increase in the positive difference between UV and UA at the end of pregnancy indicates that there is a substantial rise in placental IgG transport capacity.
CONCLUSION
All four subclasses IgG1-4 were detectable in the umbilical circulation (28-42 WG). Whereas IgG3 and IgG4 in UA and UV had a similar concentration as in MV and remained unchanged, IgG2 increased with gestation from 0.67/0.74 g/l (UA/UV, 28-33 WG) to 1.29/1.58 g/l (UA/UV, 37-42 WG), but nevertheless remained lower than the level found in the MV (2.65 +/- 1.12 g/l). The main increase in IgG concentration, however, was due to the substantial rise in the transport of IgG1, which increased from 4.37 +/- 1.24 (UA) and 4.94 +/- 1.52 g/l (UV) at 28-33 WG to 8.94 +/- 1.66 (UA) and 10.89 +/- 1.96 g/l (UV) at the end of gestation, which was even higher than the overall IgG concentration in MV.
问题
我们测定了人类妊娠晚期免疫球蛋白G（IgG）的母胎转运情况。
方法
对38例妊娠孕妇分娩时采集的外周母血静脉血（MV）、胎盘脐动脉血（UA）和脐静脉血（UV）样本中的血清进行IgG及其亚类（IgG1 - 4）浓度测定。孕周在28至42周（WG）之间。
结果
胎盘重量与孕周显著相关，而母体IgG水平及其亚类比例不随孕周变化。在28 - 33 WG（n = 15）时，UA（5.91 ± 1.53 g/l）和UV（6.41 ± 1.57 g/l）中总IgG浓度的平均值低于MV（10.74 ± 2.55 g/l）。妊娠末期（37 - 42 WG，n = 12），UA（11.21 ± 1.95 g/l）和UV（12.26 ± 2.06 g/l）中的IgG超过母体浓度（9.69 ± 1.84 g/l）。除了胎儿循环（UV + UA）中IgG浓度与孕周（28 - 42 WG）之间存在显著正相关外，妊娠末期UV与UA之间正差值的增加表明胎盘IgG转运能力大幅上升。
结论
在脐循环中可检测到所有四种IgG亚类（28 - 42 WG）。UA和UV中的IgG3和IgG4浓度与MV中的相似且保持不变，IgG2随孕周增加，从28 - 33 WG时的0.67/0.74 g/l（UA/UV）升至37 - 42 WG时的1.29/1.58 g/l（UA/UV），但仍低于MV中的水平（2.65 ± 1.12 g/l）。然而，IgG浓度的主要增加是由于IgG1转运的大幅上升，其在28 - 33 WG时UA为4.37 ± 1.24、UV为4.94 ± 1.52 g/l，到妊娠末期分别升至8.94 ± 1.66（UA）和10.89 ± 1.96 g/l（UV），甚至高于MV中的总IgG浓度。
Zotero 插件