Liu P, Bilkey D K
Department of Psychology and The Neuroscience Research Centre, University of Otago, Dunedin, New Zealand.
Behav Neurosci. 1998 Apr;112(2):304-15. doi: 10.1037//0735-7044.112.2.304.
Rats with bilateral, electrolytic lesions of perirhinal cortex (PRC), lateral entorhinal cortex (LEC), or combined lesions (PRLE) were impaired relative to controls (sham) during initial acquisition in the Morris water maze, although all groups were eventually able to learn to locate the platform. A further deficit in the performance of PRC and PRLE, but not LEC groups, was evident, however, when a probe trial was conducted 2 min (but not 24 hours) after training. When the performance of sham- and PRC-lesioned rats was tested with variable memory delays inserted between training and probe trials, lesioned rats displayed an increase in the rate of forgetting for information made available during the training trial. This finding suggests that the PRC normally stores information regarding the cue-platform relationship and transfers this information to related structures during water maze performance.
双侧电解损伤内嗅周皮质（PRC）、外侧内嗅皮质（LEC）或联合损伤（PRLE）的大鼠在莫里斯水迷宫的初始习得阶段相对于对照组（假手术组）表现受损，尽管所有组最终都能够学会找到平台。然而，当在训练后2分钟（而非24小时）进行探索试验时，PRC组和PRLE组（而非LEC组）的表现出现了进一步的缺陷。当在训练和探索试验之间插入可变记忆延迟来测试假手术组和PRC损伤大鼠的表现时，损伤大鼠在训练试验期间获得的信息遗忘率增加。这一发现表明，PRC通常存储有关线索 - 平台关系的信息，并在水迷宫实验过程中将该信息传递给相关结构。
