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前列腺素F2α(PGF2α):伤口活力的一个不充分指标?

Prostaglandin F2a (PGF2a): an inadequate marker of the vitality of wounds?

作者信息

Hernández-Cueto C, Vieira D N, Girela E, Marques E, Calvo M D, Villalobos M, Oliveira de Sà F, Villanueva E

机构信息

Department of Legal Medicine and Toxicology, Faculty of Medicine, University of Granada, Spain.

出版信息

Int J Legal Med. 1994;106(6):312-4. doi: 10.1007/BF01224777.

DOI:10.1007/BF01224777
PMID:7947338
Abstract

We have studied the viability of PGF2a as a vitality marker in skin wounds. Incised vital skin wounds and homolateral control pieces of skin were obtained from 20 autopsies performed at the Institute of Legal Medicine of Coimbra University (Portugal). We have also studied 10 fresh skin samples from the Department of Dermatology of the University Hospital (Granada). Our results show that PGF2a is not suitable for the diagnosis of the vitality of wounds because of its irregular behaviour.

摘要

我们研究了前列腺素F2α(PGF2α)作为皮肤伤口活力标志物的可行性。从葡萄牙科英布拉大学法医学研究所进行的20例尸检中获取有活力的皮肤切割伤口及同侧对照皮肤样本。我们还研究了来自格拉纳达大学医院皮肤科的10份新鲜皮肤样本。我们的结果表明,由于PGF2α行为不规律,它不适用于伤口活力的诊断。

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Int J Mol Sci. 2020 Nov 10;21(22):8435. doi: 10.3390/ijms21228435.
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Autophagy in skin wounds: a novel marker for vital reactions.皮肤伤口中的自噬:一种重要反应的新型标志物。
Int J Legal Med. 2015 May;129(3):537-41. doi: 10.1007/s00414-015-1168-4. Epub 2015 Mar 10.
3
Immunohistochemical analysis on cyclooxygenase-2 for wound age determination.免疫组织化学分析环氧化酶-2 以确定伤口的年龄。

本文引用的文献

1
Radioimmunoassay of the F prostaglandins.F 族前列腺素的放射免疫测定
J Clin Endocrinol Metab. 1971 Aug;33(2):171-5. doi: 10.1210/jcem-33-2-171.
2
[Changes in the amount of prostaglandin F2 alpha in incision wounds of the skin with different time intervals after injury].
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Prostaglandin synthesis and early biochemical events in the liver cells during the acute-phase response.
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Estimating wound age: looking into the future.估算伤口年龄:展望未来。
Int J Legal Med. 2010 Nov;124(6):523-36. doi: 10.1007/s00414-010-0505-x. Epub 2010 Sep 14.
Biosynthesis of prostaglandins.前列腺素的生物合成
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