Hernández-Cueto C, Vieira D N, Girela E, Marques E, Villanueva E, Sá F O
Department of Legal Medicine and Toxicology, University of Granada, Spain.
Forensic Sci Int. 1995 Dec 18;76(2):141-9. doi: 10.1016/0379-0738(95)01808-5.
The potential of skin measurements of D-dimer (DD), a specific derivative of crosslinked fibrin, for the diagnosis of the vital origin of wounds was investigated in 67 human vital skin wounds and homolateral control pieces of skin from 53 autopsies performed at the Institute of Legal Medicine of Coimbra (Portugal) during 1992. Our results demonstrate that DD levels for the incised vital skin wounds (n = 50) were much higher on average than their controls (P < 0.01) which were actually incised injuries produced postmortem at the autopsy. We did not find any statistical difference in average DD levels among the remaining injuries (seven abrasions and ten contusions) in comparison to their respective controls. DD may be used, with certain limitations, as a marker of the vitality of incised wounds. The authors believe this is the first time this marker has been applied in forensic pathology. It is an example of an easy and quick application technique, with the added advantage of low cost.
1992年，在葡萄牙科英布拉法医学研究所对53例尸体解剖的67处人体生前皮肤伤口及同侧对照皮肤进行研究，以探讨交联纤维蛋白的特异性衍生物D - 二聚体（DD）的皮肤测量在诊断伤口生前成因方面的潜力。我们的结果表明，切开的生前皮肤伤口（n = 50）的DD水平平均比其对照（实际上是尸检时死后造成的切开伤）高得多（P < 0.01）。与各自的对照相比，我们未发现其余损伤（7处擦伤和10处挫伤）的平均DD水平有任何统计学差异。DD在一定限制条件下可作为切开伤口生前状态的标志物。作者认为这是该标志物首次应用于法医病理学。这是一种简便快捷的应用技术实例，还具有低成本的额外优势。
