对一名艾滋病患者采用玻璃体内注射脂质体包裹的更昔洛韦治疗巨细胞病毒性视网膜炎。
Treatment of cytomegalovirus retinitis with intravitreal injection of liposome encapsulated ganciclovir in a patient with AIDS.
作者信息
Akula S K, Ma P E, Peyman G A, Rahimy M H, Hyslop N E, Janney A, Ashton P
机构信息
Department of Medicine, Tulane University Medical Center, New Orleans, LA.
出版信息
Br J Ophthalmol. 1994 Sep;78(9):677-80. doi: 10.1136/bjo.78.9.677.
To study its safety and efficacy in treating cytomegalovirus (CMV) retinitis, an AIDS patient received an intravitreal injection of liposome encapsulated ganciclovir in the right eye. The left eye served as a control, receiving intravitreal free ganciclovir. The right eye showed no retinal haemorrhages or detachment; however, vision declined initially, stabilising later. Weekly examination showed neither progression of the CMV retinitis nor new lesions in the right eye. The left eye showed reactivation of old CMV retinitis. Liposome encapsulated ganciclovir reduced the number of intravitreal injections, stabilising CMV retinitis, and warrants further study.
为研究脂质体包裹的更昔洛韦治疗巨细胞病毒（CMV）视网膜炎的安全性和有效性，一名艾滋病患者右眼接受了玻璃体内注射脂质体包裹的更昔洛韦。左眼作为对照，接受玻璃体内注射游离更昔洛韦。右眼未出现视网膜出血或脱离；然而，视力最初下降，随后稳定。每周检查显示右眼的CMV视网膜炎既无进展也无新病变。左眼显示陈旧性CMV视网膜炎复发。脂质体包裹的更昔洛韦减少了玻璃体内注射次数，使CMV视网膜炎病情稳定，值得进一步研究。
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