Szymanski L M, Pate R R
Department of Physical Education, Northern Illinois University, DeKalb 60115.
Arterioscler Thromb. 1994 Nov;14(11):1746-50. doi: 10.1161/01.atv.14.11.1746.
The purposes of this study were to compare fibrinolytic responses to moderate intensity exercise in physically active and inactive men and during morning and evening exercise. Fourteen physically inactive men (mean age, 34.7 +/- 4.0 years) and 12 regularly active men (34.8 +/- 4.0 years) performed two exercise sessions, morning and evening, at 50% of maximal oxygen consumption. Tissue plasminogen activator (TPA) and plasminogen activator inhibitor-1 (PAI-1) activity were measured before and after exercise. Data were analyzed using a three-way ANOVA with repeated measures. TPA activity increased with exercise in both groups, although the active group demonstrated greater increases than the inactive group. Postexercise TPA activity was greater with evening than morning exercise. The inactive group exhibited greater PAI-1 activity than the active group. PAI-1 activity was higher during the morning than evening but did not change with exercise for either group. We conclude that moderate intensity exercise increases TPA activity in physically active and inactive men, with greater increases seen in active men, particularly during evening exercise. Moderate intensity exercise does not appear to affect PAI-1 activity. The lower PAI-1 activity in active men may be one mechanism whereby regular physical activity lowers the risk for coronary artery disease.
本研究的目的是比较身体活动和不活动的男性在中等强度运动时以及在早晨和晚上运动时的纤溶反应。14名身体不活动的男性（平均年龄34.7±4.0岁）和12名经常运动的男性（34.8±4.0岁）在最大耗氧量的50%水平下进行了两次运动，分别在早晨和晚上。在运动前后测量组织型纤溶酶原激活物（TPA）和纤溶酶原激活物抑制剂-1（PAI-1）的活性。使用重复测量的三因素方差分析对数据进行分析。两组的TPA活性均随运动增加，尽管运动组的增加幅度大于不运动组。运动后TPA活性在晚上运动时高于早晨运动。不运动组的PAI-1活性高于运动组。PAI-1活性在早晨高于晚上，但两组的PAI-1活性均不随运动而变化。我们得出结论，中等强度运动可增加身体活动和不活动男性的TPA活性，运动男性的增加幅度更大，尤其是在晚上运动时。中等强度运动似乎不影响PAI-1活性。运动男性较低的PAI-1活性可能是规律体育活动降低冠状动脉疾病风险的一种机制。
