Szymanski L M, Pate R R
Department of Exercise Science, University of South Carolina, Columbia.
Med Sci Sports Exerc. 1994 Sep;26(9):1102-8.
The purposes of this investigation were to determine: 1) whether the fibrinolytic responses to acute, submaximal exercise were best related to intensity, duration, or total caloric expenditure; and 2) whether the time of day exercise is performed affects the fibrinolytic response. Twelve physically active men (mean age = 34.8 +/- 4.0 yr) performed four 30-min exercise sessions: 50% VO2max, a.m. and p.m., and 80% VO2max, a.m. and p.m. Blood samples were analyzed for tissue plasminogen activator (TPA) activity and plasminogen activator inhibitor-1 (PAI-1) activity. Data were analyzed using a three-way ANOVA with repeated measures. TPA activity: preexercise TPA did not differ among the four sessions. TPA increased with exercise in all sessions except the 50% a.m. session. Exercise at 80% increased TPA more than 50% (P < 0.001) and evening sessions increased TPA more than morning sessions (P < 0.05). PAI-1 activity: preexercise PAI-1 activity was higher during the morning than evening and significantly decreased with exercise in all sessions except the 50% p.m. session. It was concluded that changes in fibrinolytic activity appear to be influenced primarily by exercise intensity rather than duration or total caloric expenditure. Additionally, time of day of exercise performance significantly influenced fibrinolytic activity.
1）急性次最大运动的纤溶反应是否与强度、持续时间或总热量消耗最相关；2）运动的时间是否会影响纤溶反应。12名身体活跃的男性（平均年龄=34.8±4.0岁）进行了四次30分钟的运动：上午和下午分别进行50%最大摄氧量（VO2max）以及80%VO2max的运动。对血样进行组织纤溶酶原激活物（TPA）活性和纤溶酶原激活物抑制剂-1（PAI-1）活性分析。使用重复测量的三因素方差分析对数据进行分析。TPA活性：四次运动前的TPA无差异。除上午50%VO2max那次运动外，所有运动中TPA均随运动增加。80%VO2max运动时TPA升高幅度大于50%VO2max运动（P<0.001），且下午运动时TPA升高幅度大于上午运动（P<0.05）。PAI-1活性：运动前上午的PAI-1活性高于下午，除下午50%VO2max那次运动外，所有运动中PAI-1活性均随运动显著降低。研究得出结论，纤溶活性的变化似乎主要受运动强度影响，而非持续时间或总热量消耗。此外，运动的时间显著影响纤溶活性。
