Demiralp Tamer, Uçok Alp, Devrim Müge, Isoglu-Alkaç Ummühan, Tecer Alper, Polich John
Department of Physiology, Istanbul University, Istanbul Medical Faculty, 34390 Capa-Istanbul, Turkey.
Psychiatry Res. 2002 Aug 30;111(2-3):167-79. doi: 10.1016/s0165-1781(02)00133-6.
Auditory N2 and P3 components of event-related potentials were assessed in first-episode schizophrenic and normal control subjects (n=12/group). P3 amplitude was decreased in the patients most prominently over the frontal areas in contrast to a widespread P3 amplitude decrease reported in chronic schizophrenia. Moreover, frontal attenuation of P3 amplitude was greater in the non-medicated compared with medicated patients, a finding that suggests frontal areas are primarily affected at the onset of the first schizophrenic episode. Prolongation of N2 and P3 latencies was also observed in the patients, which indicates that stimulus classification and memory updating processes were slowed even in early stages of schizophrenia. These findings indicate that first-episode schizophrenic patients produce N2 and P3 abnormalities that are distinct from those in chronic patients, and that psychotropic medication can attenuate event-related potential effects in specific ways.
对首发精神分裂症患者和正常对照者（每组12人）的事件相关电位的听觉N2和P3成分进行了评估。与慢性精神分裂症患者广泛的P3波幅降低不同，首发患者的P3波幅在额叶区域显著降低。此外，未用药患者的P3波幅额叶衰减比用药患者更大，这一发现表明额叶区域在首发精神分裂症发作时主要受到影响。患者还出现了N2和P3潜伏期延长的情况，这表明即使在精神分裂症早期，刺激分类和记忆更新过程也会减慢。这些发现表明，首发精神分裂症患者产生的N2和P3异常与慢性患者不同，并且精神药物可以以特定方式减弱事件相关电位效应。
