Hersh D, Bauer L O, Kranzler H R
Department of Psychiatry, University of Connecticut Health Center, Farmington 06030, USA.
Drug Alcohol Depend. 1995 Oct;39(3):213-21. doi: 10.1016/0376-8716(95)01165-3.
Subjective and electroencephalographic reactions to cocaine cues were evaluated in 33 cocaine-dependent out-patients and 17 non-cocaine-dependent controls. Subjective, EEG, and autonomic reactions to three 5-min videos (cocaine-associated, erotic, neutral) were evaluated twice with an interpolated 1-week interval. Between evaluations, cocaine-dependent patients received carbamazepine 400 mg daily or matching placebo in double-blind fashion. In all three groups the cocaine-associated and erotic videos produced a comparable increase in the self-rated desire for cocaine and reduction in total EG power. Carbamazepine treatment increased EEG fast alpha power and self-rated fatigue, and decreased self-rated concentration and vigor. However, it had no specific effect on subjective or physiological reactivity to either the cocaine-associated or erotic videos. This negative finding is consistent with recent clinical trials of carbamazepine for cocaine dependence.
对33名可卡因依赖门诊患者和17名非可卡因依赖对照者评估了对可卡因线索的主观和脑电图反应。对三段5分钟视频（与可卡因相关、色情、中性）的主观、脑电图和自主反应进行了两次评估，中间间隔1周。在两次评估之间，可卡因依赖患者以双盲方式每日服用400毫克卡马西平或匹配的安慰剂。在所有三组中，与可卡因相关和色情的视频在自我评定的对可卡因的渴望方面产生了类似的增加，并且总脑电图功率降低。卡马西平治疗增加了脑电图快速α波功率和自我评定的疲劳感，降低了自我评定的注意力和活力。然而，它对与可卡因相关或色情视频的主观或生理反应没有特定影响。这一阴性结果与最近关于卡马西平治疗可卡因依赖的临床试验一致。
