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一名接受急性髓性白血病化疗的中性粒细胞减少患者发生由卷枝毛霉引起的接合菌病。

Zygomycosis due to Mucor circinelloides in a neutropenic patient receiving chemotherapy for acute myelogenous leukemia.

作者信息

Fingeroth J D, Roth R S, Talcott J A, Rinaldi M G

机构信息

Laboratory of Infectious Diseases, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.

出版信息

Clin Infect Dis. 1994 Jul;19(1):135-7. doi: 10.1093/clinids/19.1.135.

DOI:10.1093/clinids/19.1.135
PMID:7948514
Abstract

Mucor circinelloides form circinelloides has rarely been associated with human disease, even in immunocompromised patients. We report a case of cutaneous zygomycosis caused by M. circinelloides in a 23-year-old neutropenic woman receiving consolidation chemotherapy for acute myelogenous leukemia. The organism was exquisitely susceptible to amphotericin B. Despite the fact that the patient was profoundly neutropenic for an additional 3 weeks, the lesions began to resolve during therapy, and no surgical debridement was required.

摘要

卷枝毛霉很少与人类疾病相关，即使在免疫功能低下的患者中也是如此。我们报告了一例由卷枝毛霉引起的皮肤接合菌病，患者为一名23岁的中性粒细胞减少女性，正在接受急性髓性白血病巩固化疗。该菌对两性霉素B极为敏感。尽管患者在接下来的3周内仍严重中性粒细胞减少，但病变在治疗期间开始消退，无需手术清创。

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