Jarstrand C, Tunevall G
Scand J Infect Dis. 1976;8(4):229-35. doi: 10.3109/inf.1976.8.issue-4.02.
Among 197 influenza A patients admitted to Roslagstull Hospital, abundant growth of gram-negative bacilli was found in 74 cases (38%). When assays for antibodies with the patients own strains as antigen were performed on paired sera with the indirect immunofluorescence technique, titre increases were obtained in 21 out of 55 patients (38%). In this last group signs of secondary infection, as secondary pneumonia, prolonged or recurring fever or late occurrence of leukocytosis and granulocytosis, were significantly more common than in patients without gram-negative findings. An analysis of possible interference by other bacteria did not invalidate the observations. Findings of gram-negative bacilli occurred most often in patients more than 50 years of age. The bacteria were probably hospital acquired in 32 out of 55 patients. Antibody responses took place both in the IgM and the IgG fraction.
在罗斯拉格斯图尔医院收治的197例甲型流感患者中，74例（38%）发现革兰氏阴性杆菌大量生长。当采用间接免疫荧光技术，以患者自身菌株作为抗原对双份血清进行抗体检测时，55例患者中有21例（38%）抗体滴度升高。在这最后一组患者中，继发感染的迹象，如继发性肺炎、持续或反复发热或白细胞增多症和粒细胞增多症的晚期出现，比无革兰氏阴性菌发现的患者更为常见。对其他细菌可能产生干扰的分析并未使这些观察结果无效。革兰氏阴性杆菌的发现最常出现在50岁以上的患者中。在55例患者中，32例的细菌可能是医院获得性的。抗体反应在IgM和IgG组分中均有发生。
