Leandoer L, Ekelund G, Genell S, Olson S
Scand J Infect Dis Suppl. 1976(9):106-8.
The aim of the study was to evaluate the effect of two different regimens of antibiotic prophylaxis in colorectal surgery. The study comprises 57 consecutive cases. The mechanical preoperative preparation was essentially the same in all cases and the operative technique was standardized as far as possible. Antibiotic prophylaxis was started immediately before surgery and continued for three days postoperatively. Thirty-six patients received doxycycline 200 mg i.v. per day and 21 patients were given benzylpenicillin 10 million I.U. 4 times a day and streptomycin 500 mg twice a day. No major infectious complications (e.g. septicaemia, abscessess) were seen in either group. There were three wound infections in the doxycycline group and four in the penicillin-streptomycin group.
本研究的目的是评估两种不同抗生素预防方案在结直肠手术中的效果。该研究纳入了57例连续病例。所有病例术前的机械性肠道准备基本相同，手术技术也尽可能标准化。抗生素预防在手术即将开始前开始，并在术后持续三天。36例患者每天静脉注射200毫克强力霉素，21例患者每天4次肌肉注射1000万国际单位苄青霉素，每天2次肌肉注射500毫克链霉素。两组均未出现严重感染并发症（如败血症、脓肿）。强力霉素组有3例伤口感染，青霉素 - 链霉素组有4例伤口感染。
