Kammann J, Kreiner C F, Kaden P
Augenklinik, St. Johannes Hospital Dortmund.
Ophthalmologe. 1994 Aug;91(4):521-5.
Experience with intraocular lenses (IOL) made of PMMA dates back ca. 40 years, while silicone IOLs have been in use for only about 10 years. The biocompatibility of PMMA and silicone caoutchouc was tested in a comparative study investigating the growth of mouse fibroblasts on different IOL materials. Spectrophotometric determination of protein synthesis and liquid scintillation counting of DNA synthesis were carried out. The spreading of cells was planimetrically determined, and the DNA synthesis of individual cells in direct contact with the test sample was tested. The results showed that the biocompatibility of silicone lenses made of purified caoutchouc is comparable with that of PMMA lenses; there is no statistically significant difference. However, impurities arising during material synthesis result in a statistically significant inhibition of cell growth on the IOL surfaces.
聚甲基丙烯酸甲酯（PMMA）制成的人工晶状体（IOL）的使用经验可追溯到约40年前，而硅酮人工晶状体的使用时间仅约10年。在一项比较研究中测试了PMMA和硅橡胶的生物相容性，该研究调查了小鼠成纤维细胞在不同人工晶状体材料上的生长情况。进行了蛋白质合成的分光光度测定和DNA合成的液体闪烁计数。通过平面测量法测定细胞的铺展情况，并测试了与测试样品直接接触的单个细胞的DNA合成。结果表明，由纯化橡胶制成的硅酮晶状体的生物相容性与PMMA晶状体相当；没有统计学上的显著差异。然而，材料合成过程中产生的杂质会导致人工晶状体表面细胞生长受到统计学上的显著抑制。
