Jiménez-Balderas F J, Morales-Polanco M R, Gutierrez L
Department of Rheumatology, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, México DF, México.
Lupus. 1994 Jun;3(3):157-9. doi: 10.1177/096120339400300305.
This work describes the development of sideroblastic anemia (SA) during the clinical activity of systemic lupus erythematosus (SLE) in two patients. The cases refer to two women with SLE who developed SA during a relapse of the illness. Both patients fulfilled at least four criteria of the American Association of Rheumatology for SLE. In one patient, the treatment with prednisone was followed by the resolution of the SLE activity and the disappearance of the SA. Several years later there was no evidence of ringed sideroblasts or malignancy in the bone marrow. In the other patient, the clinical activity of the SLE and SA developed during the beginning of a septicemic event which finally led to her death. Our clinical cases allow us to show that the transitory development of SA can occur during a period of clinical activity of SLE and that its association, although infrequent, is due to a common physiopathogenic mechanism.
这项工作描述了两名系统性红斑狼疮（SLE）临床活动期发生铁粒幼细胞贫血（SA）的情况。这两个病例均为患有SLE的女性，她们在疾病复发期间出现了SA。两名患者均至少符合美国风湿病学会制定的SLE的四项标准。其中一名患者接受泼尼松治疗后，SLE活动得到缓解，SA消失。几年后，骨髓中未发现环形铁粒幼细胞或恶性病变。另一名患者在败血症事件开始时出现了SLE和SA的临床活动，最终导致死亡。我们的临床病例表明，SA的短暂发生可出现在SLE临床活动期，尽管其关联并不常见，但这是由于共同的生理致病机制所致。
