Rambajan I
Ministry of Health, Brickdam, Georgetown, Guyana.
Bull Pan Am Health Organ. 1994 Sep;28(3):193-201.
After being absent from North West Guyana for over two decades, falciparum malaria returned in force in 1986 and soon developed a high prevalence affecting a large share of the region's inhabitants. This falciparum upsurge was accompanied by a significant rise in the number of vivax cases that helped bring the annual parasite index to figures ranging from 260 positive smears per 1,000 inhabitants in 1986 to 973 in 1988 and 776 in 1991. The chloroquine-resistant P. falciparum strain responsible apparently travelled from the area of the Rupununi River in Southern Guyana to the more northern Cuyuni/Mazaruni/Potaro area in 1985, and from there was brought into the North West Region, probably by itinerant miners. Circumstances leading to the present endemic demonstrate how transient populations, resistant parasites, and economic restraints can interfere with malaria control, and how rapidly high malaria prevalences can establish themselves in receptive tropical areas vulnerable to attack.
在阔别圭亚那西北部二十多年后，恶性疟于1986年强势回归，很快就出现了高流行率，影响了该地区很大一部分居民。此次恶性疟激增的同时，间日疟病例数量也显著增加，这使得年度寄生虫指数从1986年每1000名居民中260份阳性涂片升至1988年的973份以及1991年的776份。导致氯喹抗性的恶性疟原虫菌株显然于1985年从圭亚那南部的鲁普努尼河地区传播到更北部的库尤尼/马扎鲁尼/波塔罗地区，并可能由流动矿工从那里带入了西北地区。导致目前这种地方病状态的情况表明，流动人口、抗药寄生虫和经济限制因素如何能够干扰疟疾控制，以及在易受侵袭的热带易感地区，高疟疾流行率能够多么迅速地形成。
