Ibeh I N, Uraih N, Ogonar J I
Department of Microbiology, Faculty of Science, Faculty of Pharmacy, University of Benin, Benin City, Nigeria.
Int J Fertil Menopausal Stud. 1994 Jul-Aug;39(4):208-14.
To discover the relationship between aflatoxin levels, if any, in serum of infertile men in comparison with random controls from the community. In a parallel experiment, adult male rats were given an aflatoxin-contaminated diet.
100 adult males, yielding 50 semen samples, from men attending Infertility Clinics at a university teaching hospital and 50 normal men in the same community.
The staple foods of the men were assayed for aflatoxin content. The rats were given the aflatoxin-rich diet, and their spermatozoa were examined and their ability to reproduce assessed.
A random sampling of semen from 100 adult males comprising 50 samples drawn from infertile men and 50 drawn from normal individuals within the same community revealed the presence of aflatoxins in 20 semen samples from the infertile group (40.0%) and four samples from the fertile group (8.0%). The mean aflatoxin concentrations were 1.660 +/- 0.04 micrograms/mL (infertile men) and 1.041 +/- 0.01 micrograms/mL (fertile men). Infertile men with aflatoxin in their semen showed a higher percentage of spermatozoal abnormality (50.0%) than the fertile men (10.0-15.0%). Dietary exposure of adult male Albino rats to aflatoxin (8.5 micrograms AF1/g of Guinea growers feed for 14 days) produced deleterious effects on the spermatozoa of the affected rats, producing features that resemble those seen in semen of infertile men exposed to aflatoxin.
探讨不育男性血清中黄曲霉毒素水平（若存在）与社区随机对照人群之间的关系。在一项平行实验中，给成年雄性大鼠喂食受黄曲霉毒素污染的饲料。
从一所大学教学医院的不育门诊招募100名成年男性，获得50份精液样本，以及同一社区的50名正常男性。
检测这些男性的主食黄曲霉毒素含量。给大鼠喂食富含黄曲霉毒素的饲料，检查其精子并评估其繁殖能力。
从100名成年男性中随机抽取精液样本，其中50份来自不育男性，50份来自同一社区的正常个体，结果显示不育组20份精液样本（40.0%）和生育组4份样本（8.0%）中存在黄曲霉毒素。黄曲霉毒素平均浓度分别为1.660±0.04微克/毫升（不育男性）和1.041±0.01微克/毫升（生育男性）。精液中含有黄曲霉毒素的不育男性精子异常百分比（50.0%）高于生育男性（10.0 - 15.0%）。成年雄性白化大鼠经饮食接触黄曲霉毒素（8.5微克AF1/克几内亚种植者饲料，持续14天）对受影响大鼠的精子产生有害影响，产生的特征与接触黄曲霉毒素的不育男性精液中所见特征相似。
